Sodium Hydroxide → 4-Amino-3-chlorobenzoic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-amino-3-chlorobenzoate (3.3 g) in ethanol (53 ml) was added 8N aqueous sodium hydroxide solution (4.4 ml), and the mixture was stirred at 40° C. for 3.5 hr. The solvent was evaporated under reduced pressure, and the residue was dissolved in water. The obtained aqueous solution was washed with diethyl ether and neutralized with 1N aqueous hydrochloric acid solution. The precipitated insoluble material was collected by filtration and air-dried to give the title compound as a pale-brown powder (3.0 g, 100%).

Provenance & Evidence