反应详情

5-[2-(Benzyloxy)ethyl]-N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (737 mg, 1.70 mmol) obtained in Example 107 was dissolved in methanol-acetic acid (25:1, 26 ml), and the mixture was stirred at room temperature for 63 hr in the presence of 10% palladium carbon (wet, purity 50%, 150 mg) under a hydrogen atmosphere. The reaction mixture was filtered to remove the catalyst, the filtrate was concentrated to dryness, and ethyl acetate-diethyl ether was added. The precipitate was collected by filtration, washed with diethyl ether and dried to give the title compound as a white powder (480 mg, 1.40 mmol, 82.2%).

1. filtrationThe reaction mixture was filtered
2. customto remove the catalyst
3. concentrationthe filtrate was concentrated to dryness, and ethyl acetate-diethyl ether
4. additionwas added
5. filtrationThe precipitate was collected by filtration
6. washwashed with diethyl ether
7. customdried