2-Methoxyethylamine → 1-{4-[(ethylamino)carbonyl]-2-(3-phenylpropoxy)phenyl}-N-(2-methoxyethyl)-1H-1,2,3-triazole-4-carboxamide

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Reaction Steps

To a solution of 1-{4-[(ethylamino)carbonyl]-2-(3-phenylpropoxy)phenyl}-1H-1,2,3-triazole-4-carboxylic acid (0.14 g) obtained in Example 133e) in DMF (4 ml) were successively added 2-methoxyethylamine (0.04 ml), triethylamine (0.06 ml), HOBt (0.07 g) and WSC (0.08 g), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture and the deposited precipitate was collected by filtration, washed with water, and recrystallized from ethanol-water to give the title compound as a white powder (0.14 g, 86%).

Provenance & Evidence