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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1717348Generated: October 26, 2026

1-Bromo-2-Chloroethane → 1-{2-(2-chloroethoxy)-4-[(ethylamino)carbonyl]phenyl}-N-cyclopropyl-5-methyl-1H-1,2,3-triazole-4-carboxamide

https://huagongshe.com/reaction/1717348

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-ChloroethaneHCID 7849—
ReactantN-cyclopropyl-1-{4-[(ethylamino)carbonyl]-2-hydroxyphenyl}-5-methyl-1H-1,2,3-triazole-4-carboxamideHCID 57664949—
SolventEthyl acetate hexaneHCID 21226206—
Product1-{2-(2-chloroethoxy)-4-[(ethylamino)carbonyl]phenyl}-N-cyclopropyl-5-methyl-1H-1,2,3-triazole-4-carboxamideHCID 57665149—

Reaction Steps

In the same manner as in Example 145, a product was obtained from N-cyclopropyl-1-{4-[(ethylamino)carbonyl]-2-hydroxyphenyl}-5-methyl-1H-1,2,3-triazole-4-carboxamide (0.17 g) obtained in Example 141 and 1-bromo-2-chloroethane (0.05 ml), and the title compound was obtained as a white powder (0.06 g, 31%) by recrystallization from ethyl acetate-hexane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803822B2
Source datasetuspto-grants-2010_09
ORD IDord-a34711267a32402fae5b0cf820d2a944
Source noteuspto-grants-2010_09