Tributylphosphine → HCID 57665153, compound

Participants

Reaction Steps

N-Cyclopropyl-1-{4-[(ethylamino)carbonyl]-2-hydroxyphenyl}-5-(hydroxymethyl)-1H-1,2,3-triazole-4-carboxamide (300 mg, 0.868 mmol) obtained in Example 317 was dissolved in THF (6.0 ml), tributylphosphine (0.300 ml, 1.13 mmol, 1.3 eq.) and ADDP (290 mg, 1.13 mmol, 1.3 eq.) were added, and the mixture was stirred at room temperature for 7 hr. The reaction mixture was diluted with ethyl acetate (10 ml), and the precipitate was collected by filtration, washed with ethyl acetate and suspended in water. The insoluble component was collected by filtration, washed with water and methanol and dried to give the title compound as a white powder (228 mg, 0.697 mmol, 80.2%).

Provenance & Evidence