Ethyl propiolate → HCID 68517597, compound

HRID 1717367Notes

Reaction equation

HRID 1717367 reaction equation
[N:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[O:14][CH2:15][CH3:16])=[N+:2]=[N-:3].[C:17]([O:21][CH2:22][CH3:23])(=[O:20])[C:18]#[CH:19]>C1(C)C=CC=CC=1>[CH2:15]([O:14][C:5]1[CH:6]=[C:7]([C:8]([O:10][CH3:11])=[O:9])[CH:12]=[CH:13][C:4]=1[N:1]1[CH:19]=[C:18]([C:17]([O:21][CH2:22][CH3:23])=[O:20])[N:3]=[N:2]1)[CH3:16]

Participants

4

Reactant 2

HCID 12182Ethyl propiolateHCID 86629811HCID 86629811, compound

Product 1

HCID 68517597HCID 68517597, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of methyl 4-azido-3-ethoxybenzoate (1.0 g) obtained in Example 320b) and ethyl propiolate (0.92 ml) in toluene (10 ml) was stirred at 100° C. overnight. After the reaction solution was allowed to cool to room temperature, the resultant precipitate was collected by filtration to give the title compound as a white solid (0.76 g).

Workup

  1. filtrationthe resultant precipitate was collected by filtration

Sources & evidence

ORD record
ord-346cd254f58b458fb0dbb4a4d1cc539b
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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