Water → HCID 68519298, compound

HRID 1717368Notes

Reaction equation

HRID 1717368 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]([O:12]C)=[O:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH:18]=[C:17]([C:19]([O:21]CC)=[O:20])[N:16]=[N:15]1)[CH3:2].[OH-].[Na+].O>C(O)C>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH:18]=[C:17]([C:19]([OH:21])=[O:20])[N:16]=[N:15]1)[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 68517597HCID 68517597, compound

Product 1

HCID 68519298HCID 68519298, compoundYield 108.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of ethyl 1-[2-ethoxy-4-(methoxycarbonyl)phenyl]-1H-1,2,3-triazole-4-carboxylate (0.92 g) obtained in Example 320c) in ethanol (10 ml) were added 8N aqueous sodium hydroxide solution (0.72 ml) and water (2 ml), and the reaction mixture was stirred at 100° C. for 1 hr. After ethanol was evaporated under reduced pressure, 1N hydrochloric acid was added to the obtained aqueous solution, and the resultant precipitant was collected by filtration to give the title compound as a white powder (0.87 g).

Workup

  1. customAfter ethanol was evaporated under reduced pressure, 1N hydrochloric acid
  2. additionwas added to the obtained aqueous solution
  3. filtrationthe resultant precipitant was collected by filtration

Sources & evidence

ORD record
ord-2dfdc7b9dd4f47b1a041af75d5b530bf
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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