反应详情

温度

120 °C

5-(Bromomethyl)-N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (890 mg) obtained in Example 321a) was dissolved in triethyl phosphite (2 ml), and the mixture was stirred at 120° C. for 3 days. An excess amount of triethyl phosphite was evaporated under reduced pressure, and the obtained residue was purified by silica gel column (ethyl acetate to ethyl acetate/methanol=4/1) to give the title compound as a colorless oil (640 mg).

1. customAn excess amount of triethyl phosphite was evaporated under reduced pressure
2. customthe obtained residue was purified by silica gel column (ethyl acetate to ethyl acetate/methanol=4/1)