HCID 57664715, compound → HCID 57665121, compound

Participants

Reaction Steps

To a solution of N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-{(E)-2-[4-(methylsulfonyl)phenyl]vinyl}-1H-1,2,3-triazole-4-carboxamide (230 mg, 0.48 mmol) obtained in Example 401 in acetic acid (12 ml) and ethanol (4.0 ml) was added palladium-carbon (25 mg). The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 5 days, and the insoluble material was filtered off. The solvent was evaporated, and the residue was purified by silica gel column (ethyl acetate/methanol=20/1 to 10/1). The resultant product was recrystallized from ethyl acetate/hexane to give the title compound as a colorless powder (150 mg, 65%).

Provenance & Evidence