HCID 68517911, compound → HCID 57665206, compound

Participants

Reaction Steps

To a mixed solution of N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[2-(3-fluorophenyl)vinyl]-1H-1,2,3-triazole-4-carboxamide (140 mg) obtained in Example 419 in ethanol/acetic acid (1/3, 8 ml) was added Pd/C (80 mg), and the mixture was stirred under a hydrogen stream for 15 hr. The catalyst was removed by filtration through celite, and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column (ethyl acetate) and recrystallized from ethyl acetate/hexane to give the title compound as a colorless powder (110 mg).

Provenance & Evidence