Water → HCID 76587193, compound

Participants

Reaction Steps

To a solution of 5-[(3-acetylphenoxy)methyl]-N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (100 mg) obtained in Example 489 in ethanol (4 ml) were added hydroxylamine hydrochloride (78 mg) and sodium acetate (92 mg), and the mixture was heated under reflux for 4 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate/hexane to give the title compound as a colorless powder (88 mg).

Provenance & Evidence