N,N-Dimethylglycine → HCID 57665233, compound

Participants

Reaction Steps

To a solution of 1-{4-[(ethylamino)carbonyl]phenyl}-5-[(3-fluorophenoxy)methyl]-N-(2-hydroxyethyl)-1H-1,2,3-triazole-4-carboxamide (500 mg) obtained in Example 498 in pyridine (10 ml) were added dimethylglycine (181 mg) and WSC (336 mg), and the mixture was stirred at room temperature for 16 hr. Water was added to the reaction mixture, and the mixture was extracted with chloroform and washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by basic silica gel column (ethyl acetate/hexane=1/1 to 2/1) and recrystallized from ethyl acetate to give the title compound as a colorless powder (432 mg).

Provenance & Evidence