Water → HCID 57664946, compound

Participants

Reaction Steps

To a solution of 1-{4-[(ethylamino)carbonyl]phenyl}-5-[(3-fluorophenoxy)methyl]-N-(2-hydroxyethyl)-1H-1,2,3-triazole-4-carboxamide (600 mg) obtained in Example 498 in THF (15 ml) were added ethyl chlorocarbonate (0.15 ml) and pyridine (0.17 ml), and the mixture was stirred under ice-cooling for 4 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate and washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column (ethyl acetate/hexane=3/1 to ethyl acetate) and recrystallized from ethyl acetate to give the title compound as a colorless powder (520 mg).

Provenance & Evidence