Hydrazine hydrate (1:1) → HCID 57664928, compound

Participants

Reaction Steps

A solution of N-cyclopropyl-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (0.9 g, 2.0 mmol) obtained in Example 1196 and hydrazine hydrate (200 mg, 4.0 mmol) in ethanol (20 ml) was boiled under reflux for 1 hr, and precipitated insoluble material was filtered off. The filtrate was concentrated to dryness to give the title compound as a white powder (0.65 g, 99%).

Provenance & Evidence