2-Chloroethyl isocyanate → 5-[3-({[(2-chloroethyl)amino]carbonyl}amino)propyl]-N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide

Participants

Reaction Steps

To a solution of 5-(3-aminopropyl)-N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (356 mg, 1 mmol) obtained in Example 1202 in THF (5 ml) was added 1-chloro-2-isocyanatoethane (106 mg, 1 mmol) at room temperature, and the mixture was stirred at room temperature for 30 min. The precipitated crystals were collected by filtration and dried to give the title compound as a white powder (450 mg, 97.4%).

Provenance & Evidence