Imidazole → HCID 57664822, compound

Participants

Reaction Conditions

Reaction Steps

(4-[(Cyclopropylamino)carbonyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazol-5-yl)propyl methanesulfonate (218 mg, 0.5 mmol) obtained in Example 1201a), potassium carbonate (83 mg, 0.6 mmol, 1.2 eq.) and imidazole (41 mg, 0.6 mmol, 1.2 eq.) were suspended in acetonitrile (5.0 ml) and the mixture was stirred at 80° C. for 10 hr. The mixture was concentrated to dryness, and the residue was purified by silica gel column (hexane/ethyl acetate=1/1 to ethyl acetate/methanol=4/1) to give the title compound as a colorless powder (42 mg, 21%).

Provenance & Evidence