HCID 68607711, compound → HCID 59306401, compound

HRID 1717450Notes

Reaction equation

HRID 1717450 reaction equation
C(C1C2CCNCC=2SC=1N[C:13](=[O:22])[CH:14]=CC1C=CC=CC=1)#N.[C:23]([C:25]1[C:33]2[CH2:32][CH2:31][NH:30][CH2:29][C:28]=2[S:27][C:26]=1[NH:34][C:35](=[O:46])[CH:36]=[CH:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[O:44][CH3:45])#[N:24].C(C1C2CCNCC=2SC=1N[C:59](=[O:69])C=CC1C=CC=CC=1Cl)#N.C(C1C2CCNCC=2SC=1NC(=[O:91])C=CC1C=NC=CC=1)#N>>[CH2:13]([O:22][C:59]([N:30]1[CH2:31][CH2:32][C:33]2[C:25]([C:23]#[N:24])=[C:26]([NH:34][C:35](=[O:46])/[CH:36]=[CH:37]/[C:38]3[C:39]4[O:44][CH2:45][O:91][C:40]=4[CH:41]=[CH:42][CH:43]=3)[S:27][C:28]=2[CH2:29]1)=[O:69])[CH3:14]

Participants

5

Reactant 4

HCID 68607711HCID 68607711, compoundHCID 68608204HCID 68608204, compoundHCID 68609167HCID 68609167, compoundHCID 68609489HCID 68609489, compound

Product 1

HCID 59306401HCID 59306401, compound

Procedure

The following compounds 112 to 127, 129, 130, 132 to 134,132 to 134, 135 to 164, and 166 to 168 can be prepared starting from the appropriate starting compound selected from N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-phenyl-acrylamide, N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-(2-methoxy-phenyl)-acrylamide, N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-(2-chloro-phenyl)-acrylamide and N-(3-cyano-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-3-(pyridin-3-yl)-acrylamide according to general procedure EE as described later herein:

Sources & evidence

ORD record
ord-434ea64f1efb44029aaff26b6d4053f3
Source dataset
uspto-grants-2010_09
Patent number
US07803945B2

Reaction notes

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