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HRID1717488

反应详情

EQUATION

反应方程式

HRID 1717488 的结构方程式

REACTANTS

反应物

3
结构：N
HCID222

Ammonia gas

H3N

结构：CC(=O)N[C@@H](CS)C(=O)O
HCID12035

N-Acetyl-L-cysteine

C5H9NO3S

结构：CC(C)(C)OC(=O)NCC#N
HCID545844

N-(tert-Butoxycarbonyl)-2-aminoacetonitrile

C7H12N2O2

PRODUCTS

生成物

1
结构：CC(=O)O.N=C(N)CNC(=O)[O-]
HCID131727841

未命名化合物

收率 62.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

N-Boc-aminoacetonitrile (40.2 g, 257.4 mmol) and N-acetylcysteine (42.0 g, 257.4 mmol) were dissolved in methanol (300 mL) at 60° C. and ammonia was passed through for 18 h. The solvent was removed in vacuo. After ion exchange chromatography (Amberlite IRA-400 (AcOH)) and recrystallisation from acetone, 28.4 g (53%) of the sub-title compound was obtained as a white solid.

WORKUP

后处理

  1. customwas passed through for 18 h
  2. customThe solvent was removed in vacuo
  3. customAfter ion exchange chromatography (Amberlite IRA-400 (AcOH)) and recrystallisation from acetone