HCID 24785288, compound → HCID 24785043, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.53 g (3.0 mmol) 1d in 15 ml methanol was added a catalytic amount of tosyl acid. The reaction mixture was stirred for 4 h at 25° C. The reaction mixture was poured in ice-cold ethyl acetate. The solution was washed twice with ice-cold diluted aqueous sodium hydrogen carbonate solution and brine and dried with magnesium sulfate. The crude product was purified by silica column chromatography (ethyl acetate:hexane gradient 1:4-1:2). The desired product 1e was obtained in 71% yield (0.91 g, 2.13 mmol) as yellow oil.

Provenance & Evidence