反应详情

To a solution of 5.75 g (10.7 mmol) crude 5b in 50 ml pyridine was added 4.37 g (42.8 mmol) acetic acid anhydride. The reaction mixture was stirred over night and poured into ice-cold ethyl acetate. The organic phase was washed with water and brine and were dried with magnesium sulfate. The crude product was purified by silica column chromatography (ethyl acetate:hexane gradient 1:8→1:4). The desired product 5c was obtained in 74.5% yield (4.62 g, 7.97 mmol).

1. additionpoured into ice-cold ethyl acetate
2. washThe organic phase was washed with water and brine
3. dry with materialwere dried with magnesium sulfate
4. customThe crude product was purified by silica column chromatography (ethyl acetate:hexane gradient 1:8→1:4)