Carbon tetrabromide → HCID 24785042, compound

Participants

Reaction Steps

To a stirred solution of 1.69 g (5.1 mmol) CBr4 and 2.89 g (11 mmol) PPh3 in dry dichloromethane (35 mL) 2.04 g (4.8 mmol) (1e) was added at 0° C. The reaction mixture was allowed to warm to room temperature and stirred overnight, then diluted with ether and filtered through sintered funnel. The filtrate was concentrated and the residue was purified by silica column chromatography (gradient hexane-ethyl acetate 6:1→2:1). The desired product 6a was obtained in 64% yield (1.37 g, 3.07 mmol).

Provenance & Evidence