Piperonyl alcohol → 1,3-Benzodioxole, 5-(chloromethyl)-

Participants

Reaction Steps

Piperonyl alcohol (45.64 g, 300 mmol) was dissolved in 340 ml of dry benzene, and SOCl2 (37 ml) was added dropwise with stirring. The solution was refluxed for 1 h, cooled and evaporated on the rotary evaporator (bath temperature less than 50° C.!). The resulting dark green residue was used without further purification.

Provenance & Evidence