Lithium Hydroxide → HCID 178445691, compound

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Enantiomer A of methyl 6-bromo-4-[(trans-4-tert-butylcyclohexyl)({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]chromane-7-carboxylate (25 mg) was saponified with aqueous LiOH and then coupled to β-alanine methyl ester HCl salt following the procedure described (Example 3/4) to give N-({6-bromo-4-[(trans-4-tert-butylcyclohexyl)({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-3,4-dihydro-2H-chromen-7-yl}carbonyl)-β-alanine. HPLC/MS: m/z=684.2 (M+1), Rt=2.50 min. 1H NMR (DMSO-d6): δ 12.20 (1H, br s), 8.56 (1H, s), 8.38 (1H, t, J=5.5 Hz), 7.46 (2H, d, J=9.0 Hz), 7.21 (2H, d, J=9.0 Hz), 6.72 (1H, s), 4.68 (1H, m), 4.36 (1H, dt, J=2.0 Hz, 11.5 Hz), 4.20 (1H, t, J=11.5 Hz), 3.90 (1H, m), 3.37 (2H, m), 2.73 (1H, m), 2.48 (2H, t, J=7.0 Hz), 1.98-1.72 (7H, m), 1.28-1.04 (4H, m), 0.88 (9H, s).

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