3-Carboxymethyl-benzoic acid ethyl ester → 3-[3-(4-Methoxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester
Reaction equation
C(OC(=O)[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]2[O:16][N:15]=[C:14]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)[N:13]=2)=[CH:7][CH:6]=1)C.[CH2:28]([O:30][C:31](=[O:42])C1C=CC=C(CC(O)=O)C=1)[CH3:29]>>[CH2:28]([O:30][C:31](=[O:42])[C:6]1[CH:5]=[CH:10][CH:9]=[C:8]([CH2:11][C:12]2[O:16][N:15]=[C:14]([CH2:17][O:18][C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)[N:13]=2)[CH:7]=1)[CH3:29]Participants
3
Procedure
The title compound is prepared essentially as described for 4-[3-(4-methoxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester, employing 3-carboxymethyl-benzoic acid ethyl ester (45%). LC-MS (m/e): 369 (M+1).
Sources & evidence
- ORD record
- ord-0aa43f302dcd4434ab4a6929cb0334fa
- Source dataset
- uspto-grants-2010_09
- Patent number
- US07803938B2
Reaction notes
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