HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-benzyloxycarbonyl-S-(2-aminophenyl)cysteine → 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-benzyloxycarbonyl-S-(2-aminophenyl)cysteine | HCID 57289832 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | HCID 13375105 | 71.7% |
Reaction Steps
17.8 g of N-benzyloxycarbonyl-S-(2-aminophenyl)cysteine was dissolved in 250 ml of xylene and the resulting solution was heated under reflux for 4 hours. After the solvent was distilled off under reduced pressure, ether was added to the residue. The precipitated crystals were separated to obtain 12.1 g of the desired compound, or 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one. Its melting point was 149°-151° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539151 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-35e37af03b4549c28624e0f3d3e4850c |
| Source note | uspto-grants-1985_09 |