HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → 2-[2-(2-Furylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramide | HCID 12788688 | — |
| Reactant | 2-(5-Furylmethylthio)ethylamine hydrochloride | HCID 20213319 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-(2-Furylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone | HCID 13505295 | — |
Reaction Steps
(b)(i) 2-Nitroamino-5-(3-pyridylmethyl)-4-pyrimidone (12.36 g) was added to a stirred mixture of 2-(5-furylmethylthio)ethylamine hydrochloride (10.65 g) and sodium ethoxide (prepared from 1.26 g sodium) in dry ethanol (300 ml) and the mixture was boiled under reflux for 44 hours and evaporated to dryness. The residue was triturated with water (discarded) and recrystallised from aqueous 2-propanol to give 2-[2-(2-furylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone, m.p. 136°-139°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539207 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-1cdceaacbcd64ee38de30c213ea4c9d1 |
| Source note | uspto-grants-1985_09 |