HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cystamine → 2-[5-(3-Pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cystamine | HCID 2915 | — |
| Reactant | 5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one | HCID 3018360 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[5-(3-Pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide | HCID 53790692 | — |
Reaction Steps
Cystamine is reacted with 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone by heating in ethanol to give 2-[5-(3-pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide which is reduced with dithiothreitol to give 2-(2-mercaptoethylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone which is reacted with 5-dimethylaminomethyl-2-furylmethanol in cold aqueous hydrochloric acid to give 2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539207 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-134cc2aa9a354edc9f55c3934bb430bd |
| Source note | uspto-grants-1985_09 |