Diethyl Ether → HCID 178511263, compound

Participants

Reaction Steps

Trans-4-Aminomethyl cyclohexane carboxylic acid (25 g; 160 mmol) in benzyl alcohol (100 cm3) and toluene (50 cm3) with para-toluene sulphonic acid monohydrate (30.2 g; 1 equivalent) was refluxed for 171/2 hours using a Dean and Stark apparatus to collect the water of condensation and from the toluene sulphonic acid monohydrate. The clear reaction mixture was poured into ether (600 cm3) and the resultant white solid filtered off, washed with ether and dried to afford 57 g (85%) of the title compound. Both infrared and nuclear magnetic resonance spectra were consistant with the desired compound.

Provenance & Evidence