HCID 13251295, compound → 4-Bromo-2-fluorobenzyl bromide

HRID 1719230Notes

Reaction equation

HRID 1719230 reaction equation
[Br:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6]N2C3C(=CC(C(F)(F)F)=CC=3)C3(C(=O)NC(=O)N3)C2=O)=[C:4]([F:29])[CH:3]=1.[Br:30]C1C=CC(C[N:36]2[C:44]3[C:39](=[CH:40][C:41]([C:45]([F:48])([F:47])[F:46])=[CH:42][CH:43]=3)[C:38](=[O:49])[C:37]2=[O:50])=C(F)C=1>>[F:48][C:45]([F:46])([F:47])[C:41]1[CH:40]=[C:39]2[C:44](=[CH:43][CH:42]=1)[NH:36][C:37](=[O:50])[C:38]2=[O:49].[Br:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][Br:30])=[C:4]([F:29])[CH:3]=1

Participants

4

Reactant 2

HCID 13251295HCID 13251295, compoundHCID 20268020HCID 20268020, compound

Product 2

HCID 27336604-Bromo-2-fluorobenzyl bromideHCID 123514965-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dione

Procedure

(Example 3): 1'-(4-bromo-2-fluorobenzyl)-5'-trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione, as a solid, m.p. 231°-232° C., starting from 1-(4-bromo-2-fluorobenzyl)-5-trifluoromethylindoline-2,3-dione (itself obtained as a syrup, of satisfctory purity by NMR, by reaction of 5-trifluoromethylindoline-2,3-dione and 4-bromo-2-fluorobenzyl bromide in an analogous manner to that described for the starting material in Example 1);

Sources & evidence

ORD record
ord-ccaa1ef8ccc64e25bfc3a612219a3f33
Source dataset
uspto-grants-1985_09
Patent number
US04539329

Reaction notes

Loading…