5-Chloropyrimidin-2-ol hydrochloride → 5-Chloro-1-{[(thiophen-2-yl)methoxy]methyl}pyrimidin-2(1H)-one

Participants

Reaction Steps

was prepared as described in Example 3 from 2-(chloromethyloxymethyl)thiophene (see Preparation 8a and 8b) (10 mmol) and 5-chloropyrimidin-2-one hydrochloride (10 mmol) in 57%. yield (1.45 g), m.p. 132° C. 1H NMR (CDCl3): δ4.80 (CH2Thioph.), 5.28 (CH2O), 6.7-7.2 (3H-Thioph.), 7.63 and 8.35 (H-4, H-6, J 4 Hz). IR(KBr): 1660 cm-1 (CO).

Provenance & Evidence