HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoropyrimidin-2-one → 1-{[(4-Chlorophenyl)methoxy]methyl}-5-fluoropyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoropyrimidin-2-one | HCID 101498 | — |
| Reactant | 1-Chloro-4-[(chloromethoxy)methyl]benzene | HCID 12946592 | — |
| Product | 1-{[(4-Chlorophenyl)methoxy]methyl}-5-fluoropyrimidin-2(1H)-one | HCID 20267942 | 70% |
Reaction Steps
was prepared as described in Example 3 from 4-chlorobenzyl chloromethyl ether (see Preparation 5a and 5b) (4 mmol) and 5-fluoropyrimidin-2-one (4 mmol) by allowing the reaction to proceed for 6 hours at room temperature; yield 70% (0.75 g), m.p. 103° C. 1H NMR (CDCl3): δ4.62 (CH2Ph), 5.30 (CH2N), 7.17 (Ph), 7.63 and 8.53 (H-4, H-6). IR(KBr): 1670 cm-1 (CO).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539324 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-0012b418b594404095b54ff06972370f |
| Source note | uspto-grants-1985_09 |