5-Bromo-2(1H)-pyrimidinone → 2(1H)-Pyrimidinone, 5-bromo-1-[(phenylmethoxy)methyl]-

HRID 1719246Notes

Reaction equation

HRID 1719246 reaction equation
Cl[CH2:2][O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Br:11][C:12]1[CH:13]=[N:14][C:15](=[O:18])[NH:16][CH:17]=1>>[CH2:4]([O:3][CH2:2][N:16]1[CH:17]=[C:12]([Br:11])[CH:13]=[N:14][C:15]1=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 1014945-Bromo-2(1H)-pyrimidinoneHCID 137983Benzyl chloromethyl ether

Product 1

HCID 111199752(1H)-Pyrimidinone, 5-bromo-1-[(phenylmethoxy)methyl]-Yield 29%

Procedure

was prepared as described in Example 3 from benzyl chloromethyl ether (see Preparation 1a and 1b) (4 mmol) and 5-bromopyrimidin-2-one by allowing the reaction to proceed for 20 hours at room temperature; yield 29% (0.34 g), m.p. 169° C. 1H NMR (CDCl3): δ4.65 (CH2Ph), 5.30 (CH2O), 7.18 (Ph), 7.78 and 8.40 (H-4, H-6, J 4 Hz). IR(KBr): 1670 cm-1 (CO).

Workup

  1. customwas prepared
  2. customthe reaction

Sources & evidence

ORD record
ord-77f04ef5fb3049bc9193b687959dcd5d
Source dataset
uspto-grants-1985_09
Patent number
US04539324

Reaction notes

Loading…