HCID 20267952, compound → HCID 14898255, compound

Participants

Reaction Steps

Dowex 50W-X8 ion exchanger in the acid form (0.29 g) was added to a solution of 1-[4-(tetrahydropyran-2-yloxymethyl)benzyloxy]methyl-5-chloropyrimidin-2-one (see Example 19) (1.2 mmol) in methanol (2 ml) and chloroform (0.5 ml) and the mixture stirred at room temperature for 2.5 hours. The ion exchanger was then removed by filtration and the filtrate evaporated to dryness at reduced pressure without heating. The residue was the title compound in the form of a non-crystalline material, obtained in 60% yield. 1H NMR (CDCl3): δ4.5-5.0 (2CH2), 5.38 (NCH2), 7.43 (Ph), 8.00 and 8.60 (H-4, H-6, J 4 Hz).

Provenance & Evidence