HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1719257Generated: October 26, 2026
Thionyl Chloride → 5-Methyl-4-imidazolecarbonyl chloride hydrochloride
https://huagongshe.com/reaction/1719257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Methyl-1H-imidazole-4-carboxylic acid hydrochloride (1:1) | HCID 13160615 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Methyl-4-imidazolecarbonyl chloride hydrochloride | HCID 20268027 | 70.1% |
Reaction Steps
To a suspension of 880 g (5.4 moles) of 5-methyl-4-imidazolecarboxylic acid hydrochloride in 100 ml of dimethylformamide and 2 liters of toluene at 60° C., there was added slowly over 2 hours 790 ml (10.8 moles) of thionyl chloride. At the end of the addition, the mixture was held with good stirring for 1 hour at 80° C. It was allowed to cool, filtered, the solid was washed with 1 liter of toluene. 685 g of 5-methyl-4-imidazolecarbonyl chloride hydrochloride were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04539331 |
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| Source dataset | uspto-grants-1985_09 |
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| ORD ID | ord-1508279536a140268bb6e1de6bc96243 |
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| Source note | uspto-grants-1985_09 |
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