Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 56611532 | HCID 56611532 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 56619348 | HCID 56619348 | — |
Reaction Steps
A solution of diazomethane in ether (2 ml) was added to a solution of [(2R,3S)-3-(1-hydroxy-1-methylethyl)-4-oxoazetidin-2-yl]acetic acid (23 mg) in methanol (3 ml) at 0° C. and the mixture was stirred for an hour at 0° C. Acetic acid (2 drops) was added to the mixture at 0° C. and the mixture was evaporated in vacuo to give methyl [(2R,3S)-3-(1-hydroxy-1-methylethyl)-4-oxoazetidin-2-yl]acetate (25 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04539152 |
|---|
| Source dataset | uspto-grants-1985_09 |
|---|
| ORD ID | ord-3ef4e6556130404e8787fe4d99eb31b1 |
|---|
| Source note | uspto-grants-1985_09 |
|---|
