huagongshe.com
HRID1719333

反应详情

EQUATION

反应方程式

HRID 1719333 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(OC(=O)OCc1ccc([N+](=O)[O-])cc1)[C@@H]1C(=O)N[C@@H]1CC(=O)C(=[N+]=[N-])C(=O)OCc1ccc([N+](=O)[O-])cc1
HCID54393073

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(OC(=O)OCc1ccc([N+](=O)[O-])cc1)[C@@H]1C(=O)N2[C@@H](C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)C[C@H]12
HCID18599211

4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-1-azabicyclo[3.2.0]heptane-2-carboxylate

C25H23N3O11

收率 98.9%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)[O-].CC(=O)[O-].[Rh+2]
催化剂HCID21674

Acetic acid, rhodium(2+) salt

C4H6O4Rh

结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of 4-nitrobenzyl 2-diazo-4-[(2R,3R)-3-{1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl}-4-oxoazetidin-2-yl]-3-oxobutanoate (1.00 g) and rhodium (II) acetate (5 mg) in benzene (50 ml) was refluxed for 25 minutes. After cooling to ambient temperature, the mixture was filtered through cellulose powder. The filtrate was evaporated to give 4-nitrobenzyl(2R,5R,6R)-3,7-dioxo-6-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-1-azabicyclo[3.2.0]heptane-2-carboxylate (0.94 g) as an amorphous solid.

WORKUP

后处理

  1. temperaturewas refluxed for 25 minutes
  2. filtrationthe mixture was filtered through cellulose powder
  3. customThe filtrate was evaporated