Methanol → Methyl 6-Bromohexanoate

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Reaction Steps

Methyl 6-bromohexanoate is prepared as follows: A solution of 6-bromohexanoic acid (10 g) in 50 ml of methanol to which was added 1.0 ml of concentrated sulfuric acid is heated under reflux for 8 hours. The methanol is distilled off, the residue is dissolved in ether. The ether solution is washed free of acid with water, dried over sodium sulfate and evaporated to dryness. Distillation at 0.8 mm Hg gives methyl 6-bromohexanoate, b.p. 85°-90°/0.8 mm.

Provenance & Evidence