Pentyl nitrite → Amyl Acetate

Participants

Reaction Steps

To the same reaction vessel as in Example 9 were charged bistriphenylphosphinedibromopalladium (0.396 g, 0.5 mmole), stannous chloride (0.190 g, 1 mmole), tetra-n-butylammonium chloride (0.278 g, 1 mmole) and n-amyl nitrite (25 ml, 171.0 mmole), together with monochlorobenzene (200 ml). Then, ketene, carbon monooxide and nitrogen were introduced to the mixture at the rate of 26.4 ml/min (1.18 mmole/min), 300 ml/min and 100 ml/min, respectively, and the reaction was performed at 90° C. for 3 hours. During the reaction, a further n-amyl nitrite (50 ml, 342.0 mmoles) was added dropwise to the reaction mixture over 2.5 hours. The reaction mixture was analyzed by gas chromatography, revealing that di-n-amyl malonate (125.6 mmoles, 59.1%) and n-amyl acetate (24.7 mmoles) were obtained.

Provenance & Evidence