HCID 13424437, compound → HCID 13491444, compound

HRID 1719428Notes

Reaction equation

HRID 1719428 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:14][CH:13]=2)=[C:6]([CH:10]=1)[C:7](O)=[O:8].[CH3:26][Li]>>[CH2:19]([O:18][C:15]1[CH:14]=[CH:13][C:12]([NH:11][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:10][C:6]=2[C:7](=[O:8])[CH3:26])=[CH:17][CH:16]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 13424437HCID 13424437, compound2×HCID 178418348HCID 178418348, compound

Product 1

HCID 13491444HCID 13491444, compoundYield 80%

Procedure

[II; R=5-Cl, R' and R"=H, OR°=4-OCH2C6H5, Alk=CH3 ] was prepared from 5-chloro-2-(4-benzyloxyphenylamino)benzoic acid and methyllithium according to the procedure of Example 1, part (a), and obtained in about 80% yield as a yellow solid, m.p. 74°-75° C. when recrystallized from cyclohexane.

Workup

  1. customobtained in about 80% yield as a yellow solid, m.p. 74°-75° C. when
  2. customrecrystallized from cyclohexane

Sources & evidence

ORD record
ord-35f8f5425ba94be9ac8fb7e06cf66c44
Source dataset
uspto-grants-1985_09
Patent number
US04539429

Reaction notes

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