HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → stearoyl-L-Ala-D-Glu(OH)OBzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Stearoyl chloride | HCID 8212 | — |
| Reactant | Bistrimethylsilylacetamid | HCID 11708267 | — |
| Reactant | Boc-L-Ala-D-Glu(OH)OMe | HCID 131713573 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | stearoyl-L-Ala-D-Glu(OH)OBzl | HCID 131713574 | 196.4% |
Reaction Steps
L-Ala-D-Glu(OH)OBzl (1) (942 mg) was suspended in methylene chloride (40 ml), and bis(trimethylsilyl)acetamide (1.20 g) was added to the suspension under stirring. The resulting solution was treated with stearoyl chloride (900 mg) at ambient temperature and left for an hour. Evaporation of the solvent gave an oily residue which was treated with water to give white solids. The solids were collected by filtration, washed with water and dried over magnesium sulfate to give stearoyl-L-Ala-D-Glu(OH)OBzl (2) (1.60 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539155 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-d047cb6153d84206b487ce4c2a2caad3 |
| Source note | uspto-grants-1985_09 |