Lactic Acid → 1,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone dilactate salt

HRID 1719464Notes

Reaction equation

HRID 1719464 reaction equation
[OH:1][CH:2]([CH3:34])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH:31]([OH:33])[CH3:32])=[CH:10][CH:9]=1.[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].C(O)C>CC(C)=O>[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].[OH:1][CH:2]([CH3:34])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH:31]([OH:33])[CH3:32])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 612Lactic AcidHCID 702EthanolHCID 4330601,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

Product 1

HCID 1317117381,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone dilactate salt

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(2-hydroxypropylamino)-ethylamino]-5,8-dihydroxyanthraquinone, 120 mg. of 80% DL-lactic acid, and 10 ml. of ethanol is heated on a steam bath for 10 minutes, cooled, treated with 50 ml. of acetone and cooled to obtain the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperaturecooled
  3. additiontreated with 50 ml

Sources & evidence

ORD record
ord-9f9c77d736de466f8bf111c7833e301f
Source dataset
uspto-grants-1985_09
Patent number
US04540519

Reaction notes

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