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HRID 1719488Notes

Reaction equation

HRID 1719488 reaction equation
[CH3:1][C@@:2]12[C:18](=[O:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.C([O-])(=O)[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1.[CH3:30][I:31].C[C:33](C)=[O:34]>>[I-:31].[CH3:30][N:24]1[CH:23]=[CH:22][CH:27]=[CH2+:26][CH:25]1[C:33]([O:20][C:9]1[CH:8]=[CH:7][C:6]2[C@@H:5]3[C@H:14]([C@H:15]4[C@@:2]([CH2:3][CH2:4]3)([CH3:1])[C:18](=[O:19])[CH2:17][CH2:16]4)[CH2:13][CH2:12][C:11]=2[CH:10]=1)=[O:34]

Participants

3

Reactant 3

HCID 180AcetoneHCID 6328Methyl iodideHCID 86740294HCID 86740294, compound

Product 0

No Product data yet.

Procedure

To estrone nicotinate (0.5 g, 0.0013 mol) in acetone (20 ml) was added methyl iodide (1 ml, 0.016 mol) and the mixture was refluxed overnight. The deep yellow precipitate was filtered, washed with acetone, and dried. Yield 90% (0.6226 g); m.p. 245°-248° C. (dec.). NMR (d5 -DMSO) δ 9.8-9.7 (br s, 1H, C2 pyridinium proton), 9.4-9.0 (m, 2H, C4, C6 pyridinium protons), 8.4-8.0 (m, 1H, C5 pyridinium proton), 7.4-7.2 (m, 1H, C1 estrone proton), 7.1-6.9 (m, 2H, C2,4 estrone protons), 3.2-1.3 (estrone skeletal protons, 15), 1.0-0.9 (s, 3H, C18 estrone protons). IR (KBr) 1755-1740 (broad C=O stretching). Anal. calculated for C25H28NO3I: C, 58.03; H, 5.47; N, 2.71. Found: C, 58.16; H, 5.51; N, 2.67. The product has the formula: ##STR752##

Workup

  1. temperaturethe mixture was refluxed overnight
  2. filtrationThe deep yellow precipitate was filtered
  3. washwashed with acetone
  4. customdried

Sources & evidence

ORD record
ord-14f34cb569da44b9901a3985a3277adf
Source dataset
uspto-grants-1985_09
Patent number
US04540564

Reaction notes

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