HCID 12538206, compound → HCID 54712701, compound

Participants

Reaction Steps

A solution of methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (2.4 g) and 2-amino-4-methyl-2,4,6-cycloheptatrien-1-one (1.3 g) in xylene (50 ml) is refluxed for 7 hours. The reaction mixture is then allowed to stand at room temperature overnight. The resulting crystals (1.0 g) are collected by filtration and recrystallized from dioxane to give 4-hydroxy-2-methyl-N-(4-methyl-1-oxo-2,4,6-cycloheptatrien-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (0.8 g), m.p. 235°-242° C.

Provenance & Evidence