HCID 12557655, compound → HCID 54712702, compound

Participants

Reaction Steps

A solution of methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (1.5 g) and 2-amino-7-methoxy-2,4,6-cycloheptatrien-1-one (0.8 g) in xylene (25 ml) is refluxed for 6.5 hours. The reaction mixture is then allowed to stand at room temperature overnight. The crystals that have separated out are collected by filtration and recrystallized from dimethylformamide to give 4-hydroxy-2-methyl-N-(7-methoxy-1-oxo-2,4,6-cycloheptatrien-2-yl)-2H-1,2 -benzothiazine-3-carboxamide 1,1-dioxide (0.7 g), m.p. 243°-247° C.

Provenance & Evidence