methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide → HCID 178481150, compound

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Reaction Steps

A mixture of methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (0.65 g) and 2-amino-5-hydroxy-2,4,6-cycloheptatrien-1-one (0.40 g) in xylene (12 ml) was refluxed for 48 hours. The reaction mixture was cooled to room temperature. The crystals were collected by filtration and washed successively with methanol, water and methanol to give 4-hydroxy-N-(5-hydroxy-1-oxo-2,4,6-cycloheptatrien-2-yl)-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (0.4 g).

Provenance & Evidence