HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidine → 2,4-Dimethoxy-5,6-bis(methylthio)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidine | HCID 9260 | — |
| Reactant | 4-Chloro-2,6-dimethoxy-5-(methylsulfanyl)pyrimidine | HCID 15590370 | — |
| Reactant | Methylmercaptan sodium | HCID 45051789 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,4-Dimethoxy-5,6-bis(methylthio)pyrimidine | HCID 403425 | — |
Reaction Steps
Into a 100-milliliter, 4-necked flask equipped with a reflux condenser, thermometer and stirrer, were charged 5.51 g of 6-chloro-2,4-dimethoxy-5-methylthiopyrimidine and 50 ml of tetrahydrofuran. After causing the pyrimidine derivative to dissolve completely in the solvent, a 15% aqueous solution of sodium methyl mercaptan (commercially available; product of Tokyo Kasei Kogyo K.K.) was added dropwise and the resultant mixture was refluxed for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04540698 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-86eadd4f0fa04367abd8021d56bc4621 |
| Source note | uspto-grants-1985_09 |