反应详情

Charged into a 100-milliliter, 4-necked flask equipped with a reflux condenser, thermometer and stirrer were 2.2 g of 6-chloro-2,4-dimethoxy-5-methylthiopyrimidine and 40 ml of methanol. They were stirred into a homogeneous solution. Subsequent to an addition of 2.0 g of potassium hydroxide, the resultant mixture was heated and refluxed, with thorough stirring, for 3 hours. The liquid reaction mixture was then poured into water and the resultant solid precipitate was collected by filtration. It was recrystallized from isopropyl alcohol, thereby obtaining 5-methylthio-2,4,6-trimethoxypyrimidine (m.p. 90°-91° C.). Yield: 1.96 g(90.7%).

1. additionCharged into a 100-milliliter, 4-necked flask
2. customequipped with a reflux condenser
3. customthermometer and stirrer were
4. temperaturerefluxed, with thorough stirring, for 3 hours
5. customThe liquid reaction mixture
6. filtrationthe resultant solid precipitate was collected by filtration
7. customIt was recrystallized from isopropyl alcohol