Sodium Chloride → HCID 13187707, compound

Participants

Reaction Conditions

Reaction Steps

2-Acetyl-2-acetamino-1,2,3,4-tetrahydro-5,8-dimethoxynaphthalene (2.8 g), phthalic anhydride (3.4 g), aluminum chloride (40 g) and sodium chloride (8 g) were pulverized and mixed well and charged in a flask previously heated at 180° C. Heating was continued at 180° C. to melt the contents. After melting, heating was further continued for 2 minutes. Then, the temperature was quickly lowered to room temperature, followed by incorporation of a saturated oxalic acid solution (500 ml) cooled with ice water therein. The resultant mixture was stirred at room temperature for 10 minutes. The precipitated crystals were collected by filtration to give 9-acetyl-9-acetamino-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione. M.P., 295°-303° C. (decomp.).

Provenance & Evidence