Acetyl chloride → HCID 13187734, compound

Participants

Reaction Steps

A mixture of 9-amino-9-acetyl-6,7,11-trihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione hydrochloride (130 mg), sodium carbonate (400 mg), a saturated sodium bicarbonate solution (20 ml), chloroform (10 ml) and tetrahydrofuran (10 ml) was stirred vigorously, and acetyl chloride (200 mg) was dropwise added thereto at room temperature. After the dropwise addition was completed, stirring was continued for 30 minutes. The reaction mixture was shaken with chloroform (50 ml). The chloroform layer was separated, washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was recrystallized from diethyl ether to give 9-acetyl-9-acetamino-6,7,11-trihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione. M.P., 240°-248° C.

Provenance & Evidence