Hydrochloric Acid → HCID 13491462, compound

Participants

Reaction Steps

A mixture of 9-acetyl-9-acetamino-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione (3.0 g), acetic acid (90 ml) and conc. hydrochloric acid (60 ml) was heated under reflux for 9 hours. The reaction mixture was concentrated under reduced pressure. The residue was admixed with a saturated sodium bicarbonate solution (1000 ml), followed by stirring for 1 hour. The precipitated crystals were collected by filtration to give 9-acetyl-9-amino-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione (2.6 g). M.P., 190°-195° C.

Provenance & Evidence